NGR peptide Trifluoroacetate
|Size||Stock||Price||Quantity||Add to Cart||Quotation Online|
|1mg||In-stock||$100.0 $130.0 $100.0|
|5mg||In-stock||$300.0 $390.0 $300.0|
|Name:||NGR peptide Trifluoroacetate; CNGRCG Trifluoroacetate|
|Cat. No. :||CS-7687|
|CAS No. :|
|M. Wt. :||722.7153896|
|Solubility:||H2O: ≥ 100 mg/mL|
NGR peptide Trifluoroacetate is the peptide containing the asparagine-glycine-arginine (NGR) motif are recognized by CD13/aminopeptidase N (APN) receptor isoforms that are selectively overexpressed in tumor neovasculature. IC50 & Target: CD13/aminopeptidase N (APN) receptor In Vitro: NGR peptide can selectively bind to APN/CD13 either immune-captured or expressed on the surface of cells, the receptor of the tumor-homing NGR peptide was suspected to be APN/CD13. The NGR peptide is reported to have the greatest tumor selectivity. An anti-cancer drug Doxorubicin (DOX) coupled to an NGR peptide displays enhanced anti-tumor effects with even lower toxicity than the free drug itself. In Vivo: NGR peptide imaging in vivo not only provides more insight into NGR’s targeting process, including bio-distribution and pharmacokinetics, but also reveals angiogenic activities related to tumor progression and malignancy.
Wang RE, et al. Development of NGR peptide-based agents for tumor imaging. Am J Nucl Med Mol Imaging. 2011;1(1):36-46.
Enyedi KN, et al. NGR-peptide-drug conjugates with dual targeting properties. NGR-peptide-drug conjugates with dual targeting properties.
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