NGR peptide Trifluoroacetate

NGR peptide Trifluoroacetate
Cat. No. : CS-7687
M. Wt. : 722.72
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5mg In-stock $360.0
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  • Data Sheet

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Name: NGR peptide Trifluoroacetate; CNGRCG Trifluoroacetate
Cat. No. : CS-7687
CAS No. :    
Formula: C22H37F3N10O10S2
M. Wt. : 722.72
Solubility: H2O: ≥ 100 mg/mL

Activity:

NGR peptide Trifluoroacetate containing the asparagine-glycine-arginine (NGR) motif is recognized by CD13/aminopeptidase N (APN) receptor isoforms that are selectively overexpressed in tumor neovasculature. IC50 & Target: CD13/aminopeptidase N (APN) receptor[1] In Vitro: NGR peptide can selectively bind to APN/CD13 either immune-captured or expressed on the surface of cells, the receptor of the tumor-homing NGR peptide was suspected to be APN/CD13. The NGR peptide is reported to have the greatest tumor selectivity. An anti-cancer drug Doxorubicin (DOX) coupled to an NGR peptide displays enhanced anti-tumor effects with even lower toxicity than the free drug itself[2]. In Vivo: NGR peptide imaging in vivo not only provides more insight into NGR’s targeting process, including bio-distribution and pharmacokinetics, but also reveals angiogenic activities related to tumor progression and malignancy[2].

Protocol:

References:

Wang RE, et al. Development of NGR peptide-based agents for tumor imaging. Am J Nucl Med Mol Imaging. 2011;1(1):36-46.

Enyedi KN, et al. NGR-peptide-drug conjugates with dual targeting properties. NGR-peptide-drug conjugates with dual targeting properties.

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    • CS-7687 26225
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