Lot numbers can be found on the outside label of a product:
|Size||Stock||Price||Quantity||Add to Cart||Quotation Online|
|Name:||RG7800 hydrochloride; RO6885247 hydrochloride|
|Cat. No. :||CS-0044495|
|CAS No. :|
|M. Wt. :|
|Solubility:||H2O: ≥ 113.5 mg/mL|
RG7800 hydrochloride is an orally active SMN2 splicing modulator, with EC1.5xs of 23 nM and 87 nM for SMN2 splicing and SMN protein; RG7800 hydrochloride has the potential to treat spinal muscular atrophy. IC50 & Target: EC1.5x: 23 nM (SMN2 splicing), 87 nM (SMN protein) In Vitro: RG7800 hydrochloride is an orally active SMN2 splicing modulator, with EC1.5xs of 23 nM and 87 nM for SMN2 splicing and SMN protein; and is the first small molecule SMN2 splicing modifier to enter human clinical trials. In Vivo: RG7800 is a favorable agent metabolism and pharmacokinetic (DMPK) profile in the rat and in cynomolgus monkey with good oral bioavailability. RG7800 (1, 3, 10 mg/kg, p.o.) dose-dependently elevates the SMN protein level in the brain and in peripheral tissue of Δ7 mice.
Protocol:Animal Administration: RG7800 is dissloved in DMSO for i.p. administration. RG7800 is formulated in 0.5% HPMC and 0.1% Tween 80 for oral administration.Mice
Homozygous Δ7 mice are dosed ip with RG7800 or vehicle (100% DMSO, 2.5 mL/kg) once per day from PND3 through postnatal day 3 (PND23), and the dosing regimen is switched on PND24 to a 3-fold higher oral dose once daily in 0.5% HPMC and 0.1% Tween 80. Litters are randomized across groups. Body weight and survival are assessed daily. Survival analysis is done using GraphPad Prism (log-rank test), and a p <0.05 is considered as significant.
Ratni H, et al. Specific Correction of Alternative Survival Motor Neuron 2 Splicing by Small Molecules: Discovery of a Potential Novel Medicine To Treat Spinal Muscular Atrophy. J Med Chem. 2016 Jul 14;59(13):6086-100.
We apologize for the inconvenience. The Certificate of Analysis you requested is not currently available on-line:
1. The Lot Number you requested may have been entered incorrectly. How to get a Lot Number
2. The COA of the Lot you requested has not been added to our database.
|Tags:RG7800 hydrochloride supplier,RG7800 hydrochloride purchase,RG7800 hydrochloride manufacturer,RG7800 hydrochloride sigma,RG7800 hydrochloride distributor,cost,RG7800 hydrochloride buy,RG7800 hydrochloride for sale|