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Home   »   Product Pathways  »  JNK  »  CC-401

Products are for research use only. Not for human use. We do not sell to patients.

CS-1955 CC-401

(CC401;CC 401)
Structure Price and Availability of    CC-401
United States
Size Price Stock
5mg $150 Backordered Inquiry Please send us inquire for the availability about
10mg $270 Backordered
50mg $800 Backordered
100 mg Get quote
200 mg Get quote
 Distributor In Japan:  フナコシ株式会社    電話番号:81-3-5684-1620   
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CC-401  M.Wt:  388.47
CC-401  Formula: C22H24N6O
CC-401  Solubility: 10 mM in DMSO
CC-401  Purity: >98%
CC-401  Storage:  Please store the product under the recommended conditions in the Certificate of Analysis.
CAS: 395104-30-0

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CC-401 is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity. IC50 value: Target: JNK In vitro: JNK inhibition decreased cytochrome c release, caspase 3 activation (P<0.05), and lipid peroxidation (P<0.05). JNK inhibition also transiently blocked phosphorylation of c-Jun at 60 minutes after reperfusion (P<0.05) without affecting other MAPK signaling, including p-38 and Erk activation [1]. in vivo: In acute disease, CC-401 blocked JNK signaling and reduced proteinuria in the first 24 h. The transient neutrophil influx seen at 3 h of disease was not affected, however. Continued CC-401 treatment suppressed glomerular and tubulointerstitial damage usually seen at 14 days [2]. Administration of CC-401 to rats prior to bilateral renal I/R prevented acute renal failure and largely prevented tubular damage, leucocyte infiltration and upregulation of pro-inflammatory molecules. However, delaying CC-401 treatment until 1 h after reperfusion (after the peak of JNK activation) had no protective effect [3].

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