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Home   »   Product Pathways  »  Cancer  »  BMN-673

Products are for research use only. Not for human use. We do not sell to patients.

CS-0937 BMN-673

(Talazoparib;BMN673; BMN 673)
Structure Price and Availability of    BMN-673
United States
Size Price Stock
5mg $185 In-stock Inquiry
10mg $300 In-stock
50mg $650 In-stock
100mg $1200 In-stock
200 mg Get quote
500 mg Get quote
 Distributor In Japan:  フナコシ株式会社    電話番号:81-3-5684-1620   
Inquiry for price and availability only. Please place your order via our email or fax.
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BMN-673  M.Wt: 380.35
BMN-673  Formula: C19H14F2N6O
BMN-673  Solubility: DMSO 75 mg/mL; Water <1 mg/mL; Ethanol <1 mg/mL
BMN-673  Purity: >98%
BMN-673  Storage:  Please store the product under the recommended conditions in the Certificate of Analysis.
CAS: 1207456-01-6

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BMN 673 is a novel PARP1/2 inhibitor with IC50 of 0.58 nM(PARP1); does not inhibit PARG and is highly sensitive to PTEN mutation. IC50 Value: 0.58 nM Target: PARP BMN-673 is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. PARP inhibitor BMN-673 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks. BMN-673 has been proven to be highly active in mouse models of human cancer and also appears to be more selectively cytotoxic with a longer half-life and better bioavailability as compared to other compounds in development.

PARP  |  
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Products are for research use only. Not for human use. We do not sell to patients. Sitemap | Inhibitor © Copyright 2012. All Rights Reserved.