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Home   »   Product Pathways  »  JAK  »  AZ960

Products are for research use only. Not for human use. We do not sell to patients.

CS-6209 AZ960

(AZ-960;AZ 960)
Structure Price and Availability of    AZ960
United States
Size Price Stock
1mg $90 In-stock Inquiry
2mg $150 In-stock
5mg $260 In-stock
10mg $400 In-stock
50mg $1200 In-stock
100 mg Get quote
200 mg Get quote
 Distributor In Japan:  フナコシ株式会社    電話番号:81-3-5684-1620   
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AZ960  M.Wt:  354.36
AZ960  Formula: C18H16F2N6
AZ960  Solubility: ≥30 mg/mL in DMSO
AZ960  Purity: >98%
AZ960  Storage:  Please store the product under the recommended conditions in the Certificate of Analysis.
CAS: 905586-69-8

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AZ960 is a potent and specific inhibitor of the JAK2 kinase with a Ki of 0.45 nM. Ki&Target: 0.45 nM (JAK2)[1] InVitro: AZ960 inhibits Jak2 kinase with a Ki of 0.45 nM. Z960 possesses much less potent activity against Jak1, 3, and TYK2. AZ960 is active against other kinases, including TrkA, Aurora-A, and FAK, with IC50 of around 0.1 μM. AZ960 effectively induces growth arrest and apoptosis of human T-cell lymphotropic virus type 1, HTLV-1–infected T cells (MT-1 and MT-2) in parallel with downregulation of the phosphorylated forms of Jak2 and Bcl-2 family proteins including Bcl-2 and Mcl-1[2]. AZ960 potently inhibits the clonogenic growth and induces apoptosis of freshly isolated acute myelogenous leukemia cells from patients in association with cleavage of caspase 3 and down regulation of anti-apoptotic Bcl-xL proteins[1]. AZ960 has a Ki of 1.25 μM for T. brucei extracellular signal-regulated kinase 8 (TbERK8). It inhibits TbERK8 with an IC50 of 120 nM[3].

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Products are for research use only. Not for human use. We do not sell to patients. Sitemap | Inhibitor © Copyright 2012. All Rights Reserved.