AZ-23
CAS No. : 915720-21-7

AZ-23
Cat. No. : CS-0007790
M. Wt. : 391.83
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  • Data Sheet

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Name: AZ-23; AZ23; AZ 23
Cat. No. : CS-0007790
CAS No. : 915720-21-7
Formula: C17H19ClFN7O
M. Wt. : 391.83
Solubility: DMSO

Activity:

AZ-23 is a potent, orally bioavailable Trk kinase inhibitor with IC50s of 2 nM (TrkA), 8 nM (TrkB), 24 nM (FGFR1), 52 nM (Flt3), 55 nM (Ret), 84 nM (MuSk), 99 nM (Lck), respectively. IC50 & Target: IC50:2 nM (TrkA), 8 nM (TrkB), 24 nM (FGFR1), 52 nM (Flt3), 55 nM (Ret), 84 nM (MuSk), 99 nM (Lck)[1].

Protocol:

References:

Thress K, et al. Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway. Mol Cancer Ther. 2009 Jul; 8(7):1818-27.

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