Polyvinylpyrrolidone
CAS No. : 9003-39-8

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  • Data Sheet

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Name: Polyvinylpyrrolidone; PVP; Polyvidone; Povidone
Cat. No. : CS-7744
CAS No. : 9003-39-8
Formula: (C6H9NO)n
M. Wt. : 111.1418(monomer)
Solubility: 10 mM in DMSO

Activity:

Polyvinylpyrrolidone is a compound which has been widely tested and used in human and veterinary medicine as an effective wound healing accelerator and disinfectant when combined with iodine and other compounds. In Vivo: Goldfishes which are treated with salt have significantly lower mucus weights at 25 h. Goldfishes treated with Polyvinylpyrrolidone (PVP) have significantly higher mucus weights at 25 h. Koi treated with salt and Polyvinylpyrrolidone (PVP) has significantly lower mucus weight at 1 and 25 h. Control koi has significantly higher mucus at 25 h. At the end of 2 weeks, it is determined that the three koi treated with salt and Polyvinylpyrrolidone(PVP) remain healthy and show a higher degree of healing than other treatment koi and the control group[1].

Protocol:

Animal Administration: [1]Each fish within a tank serves as a replicate. Treatments are designated as Stress Coat® (at a dose of 10 mL/10 gallon), Polyvinylpyrrolidone (PVP) only (at a dose of 10 mL/10 gallon), Stress Coat® w/o Polyvinylpyrrolidone formulation (at a dose of 10 mL/10 gallon) and (saline/salt at 3g/L). A control group that does not receive any chemical is also included in the study. All fishes from each treatment group are sampled at 0 min, 15 min, 1 h, 4 h and 25 h. At each time interval, all fishes from each treatment group are anaesthetized using buffered tricaine methanesulfonate (MS-222) at a dose of 200 mg/L, weighed, and slime is scraped from one 1 cm2 area over the epaxial musculature using a preweighed plastic coverslip[1].

References:

Shivappa RB, et al. Laboratory evaluation of different formulations of Stress Coat® for slime production in goldfish (Carassius auratus) and koi (Cyprinus carpio). PeerJ. 2017 Sep 6;5:e3759.

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