GLX351322
CAS No. : 835598-94-2

GLX351322
Cat. No. : CS-0018088
M. Wt. : 431.51
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Name: GLX351322; GLX-351322; GLX 351322
Cat. No. : CS-0018088
CAS No. : 835598-94-2
Formula: C21H25N3O5S
M. Wt. : 431.51
Solubility: DMSO

Activity:

GLX351322 is an inhibitor of NADPH oxidase 4, and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μ M. IC50 & Target: IC50: 5 μ M (NOX4, cell assay), 40 μM (NOX2, cell assay)[1] In Vitro: GLX351322 is an inhibitor of NADPH oxidase 4, and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μM. GLX351322 shows weak activity against NOX2 in hPBMC cells (IC50, 40 μM). In Vivo: GLX351322 (3.8 mg/kg/day, p.o.) ameliorates HFD-induced hyperglycemia in mice[1].

Protocol:

References:

Anvari E, et al. The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice. Free Radic Res. 2015;49(11):1308-18.

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