β-Secretase Inhibitor IV
CAS No. : 797035-11-1

β-Secretase Inhibitor IV
Cat. No. : CS-0002466
M. Wt. : 578.72
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  • Data Sheet

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Name: β-Secretase Inhibitor IV; Axon 1125
Cat. No. : CS-0002466
CAS No. : 797035-11-1
Formula: C31H38N4O5S
M. Wt. : 578.72
Solubility: DMSO

Activity:

β-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively. IC50 & Target: IC50: 15.3±0.6 nM (BACE-1), 230±26 nM (BACE-2), 7620±210 nM (Cathepsin D)[1] In Vitro: In the cell culture assay, β-Secretase Inhibitor IV (Compound 2) inhibits the production of Aβ peptides with an EC50 of 43 nM. β-Secretase Inhibitor IV potently suppresses the secretion of sAPP_NF and EV40 from HEK293T cells with an IC50 near 30 nM[1].

Protocol:

References:

Pietrak BL, et al. Biochemical and cell-based assays for characterization of BACE-1 inhibitors. Anal Biochem. 2005 Jul 1;342(1):144-51.

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