DM4

DM4
Cat. No. : CS-6866 CAS No. : 796073-69-3
M. Wt. : 780.37
Size Stock Price Quantity Add to Cart Quotation Online
1mg In-stock $110.0
5mg In-stock $330.0
10mg In-stock $500.0
50mg In-stock $1500.0
100mg In-stock $2100.0
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  • Data Sheet

  • Introduction

  • SDS

  • COA & Spectra

Name: DM4; 
Cat. No. : CS-6866
CAS No. : 796073-69-3
Formula: C38H54ClN3O10S
M. Wt. : 780.37
Solubility: DMSO: 10 mM

Activity:

DM4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody drug conjugate. In Vitro: DM4, a structural analogue of maytansine, is a new thiol-containing and potent maytansinoid. DM4 is a cytotoxic maytansinoid drug. It is synthesized in order to link maytansinoids to antibodies via disulfide bonds. Maytansinoids inhibit tubulin polymerization and microtubule assembly and enhance microtubule destabilization, so there is potent suppression of microtubule dynamics resulting in a mitotic block and subsequent apoptotic cell death[1].

Protocol:

References:

Tang R, et al. P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients. BMC Cancer. 2009 Jun 23;9:199.

  • Select Batch :
    • CS-6866 24821
    • CS-6866 25939
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