Herniarin
CAS No. : 531-59-9

Herniarin
Cat. No. : CS-0016775
M. Wt. : 176.17
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100mg In-stock $50.0
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  • Data Sheet

  • Introduction

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  • COA & Spectra

Name: Herniarin; 7-Methoxycoumarin; Methyl umbelliferyl ether
Cat. No. : CS-0016775
CAS No. : 531-59-9
Formula: C10H8O3
M. Wt. : 176.17
Solubility: DMSO: ≥ 125 mg/mL

Activity:

Herniarin is a natural coumarin occurs in some flowering plants, with antitumor effect. In Vitro: Herniarin is cytotoxic to breast carcinoma cell line MCF-7 with an IC50 of 207.6 µM. Herniarin (100 µM) also induces apoptosis in MCF-7 cells[1]. Herniarin alone has no obvious cytotoxicity on transitional cell carcinoma (TCC) cells, but when in combination with 5 µg/mL cisplatin, Herniarin (80 µg/mL) potently enhances the antitumor effect of cisplatin, and increases chromatin condensation[2].

Protocol:

Cell Assay: Herniarin is dissolved in DMSO[1].[1]Briefly, the cells are seeded (104 cells per well) onto flat-bottomed 96-well culture plates and allowed to grow 72 h after treatment with various concentration of auraptene, Herniarin, umbelliferone, and umbelliprenin. After removing the medium, MTT solution (5 mg/mL in PBS) is added and incubated for 4 h and the resulting formazan is solubilized with DMSO (100 mL). The absorption is measured at 570 nm (620 nm as a reference) in an ELISA reader[1].

References:

Haghighitalab A, et al. Enhancement of cisplatin cytotoxicity in combination with herniarin in vitro. Drug Chem Toxicol. 2014 Apr;37(2):156-62.

Mousavi SH, et al. Comparative analysis of the cytotoxic effect of 7-prenyloxycoumarin compounds and herniarin on MCF-7 cell line. Avicenna J Phytomed. 2015 Nov-Dec;5(6):520-30.

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