1-O-Acetylbritannilactone
CAS No. : 33627-41-7

1-O-Acetylbritannilactone
Cat. No. : CS-3742
M. Wt. : 308.37
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  • Data Sheet

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Name: 1-O-Acetylbritannilactone; Inulicin
Cat. No. : CS-3742
CAS No. : 33627-41-7
Formula: C17H24O5
M. Wt. : 308.37
Solubility: 10 mM in DMSO

Activity:

1-O-Acetylbritannilactone(Inulicin) is a sesquiterpene isolated from the medicinal plant Inula britannica; anticancer and anti-inflammation acitvity. IC50 value: Target: in vitro: 1-O-Acetylbritannilactone significantly reduced melanin production in a dose-dependent manner with IC50 value of 13.3 uM. inhibited melanogenesis by activating extracellular signal-regulated kinase (ERK) and Akt signaling and also inhibiting cAMP related binding protein, which regulates its downstream pathway, including tyrosinase, tyrosinase related protein-1 and TRP-2 [2]. ABL (5, 10, 20 micrommol/l) had several concentration-dependent effects, including inhibition of lipopolysaccharide (LPS)-induced PGE(2) production and COX-2 expression, and blockade of NF-kappaB activation and translocation [3]. 1-O-Acetylbritannilactone is a potent inhibitor of LPS-stimulated VSMC inflammatory responses through blockade of NF-kappaB activity and inhibition of inflammatory gene COX-2 expression.

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References:

Liu YP, et al. Acetylbritannilactone suppresses lipopolysaccharide-induced vascular smooth muscle cell inflammatory response. Eur J Pharmacol. 2007 Dec 22;577(1-3):28-34.

Choo SJ, et al. Hypo-pigmenting effect of sesquiterpenes from Inula britannica in B16 melanoma cells. Arch Pharm Res. 2014 May;37(5):567-74.

Dong S, et al. Semisynthesis and in vitro cytotoxic evaluation of new analogues of 1-O-acetylbritannilactone, a sesquiterpene from Inula britannica. Eur J Med Chem. 2014 Jun 10;80:71-82.

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