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|Name:||Fesoterodine fumarate; Toviaz|
|Cat. No. :||CS-0822|
|CAS No. :||286930-03-8|
|M. Wt. :||527.649|
|Solubility:||10 mM in DMSO|
Fesoterodine Fumarate is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a muscarinic receptor antagonist. IC50 value: Target: mAChR Fesoterodine has the advantage of allowing more flexible dosage than other muscarinic antagonists. Its tolerability and side effects are similar to other muscarinic antagonists and as a new drug seems unlikely to make great changes in practices of treatment for overactive bladder.
Staskin David; Khullar Vik; Michel Martin C et al. Effects of voluntary dose escalation in a placebo-controlled, flexible-dose trial of fesoterodine in subjects with overactive bladder. Neurourology and urodynamics (2011), 30(8), 1480-5.
Michel MC. Fesoterodine: a novel muscarinic receptor antagonist for the treatment of overactive bladder syndrome. Expert Opin Pharmacother. 2008 Jul;9(10):1787-96.
Malhotra Bimal; Alvey Christine; Gong Jason et al. Effects of fesoterodine on the pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers. British journal of clinical pharmacology (2011), 72(2), 257-62.
Vella Maria; Cardozo Linda Review of fesoterodine. Expert opinion on drug safety (2011), 10(5), 805-8.
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