STAT5-IN-1

STAT5-IN-1
Cat. No. : CS-6859 CAS No. : 285986-31-4
M. Wt. : 293.28
Size Stock Price Quantity Add to Cart Quotation Online
5mg In-stock $50.0
10mg In-stock $90.0
25mg In-stock $190.0
50mg In-stock $340.0
100mg In-stock $600.0
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  • Data Sheet

  • Introduction

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  • COA & Spectra

Name: STAT5-IN-1; 
Cat. No. : CS-6859
CAS No. : 285986-31-4
Formula: C16H11N3O3
M. Wt. : 293.28
Solubility: DMSO: ≥23.0 mg/mL

Activity:

STAT5-IN-1 is a STAT5 inhibitor with an IC50 of 47 μM for STAT5β isoform. IC50 & Target: IC50: 47 μM (STAT5β)[1] In Vitro: The signal transducer and activator of transcription 5 (STAT5) is a member of the STAT family of proteins, implicated in cell growth and differentiation. STAT5-IN-1 inhibits STAT5 by binding to the SH2 domain. The functions of the SH2 domains of STAT3, STAT1, and of the tyrosine kinase Lck are inhibited to a lesser extent (IC50>500 µM). STAT5-IN-1 block STAT5/STAT5 DNA binding in K562 nuclear extracts. Substitution of the hydrogen at C6 of the chromone ring by an ethyl group does not affect activity of STAT5-IN-1 against STAT5β, but leads to complete loss of selectivity against other STAT family members[1].

Protocol:

References:

Müller J, et al. Discovery of chromone-based inhibitors of the transcription factor STAT5. Chembiochem. 2008 Mar 25;9(5):723-7.

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    • CS-6859 24793
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