CAS No. : 2552-55-8
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|Name:||Ibotenic acid; (RS)-Ibotenic acid; DL-Ibotenic acid|
|Cat. No. :||CS-0020472|
|CAS No. :||2552-55-8|
|M. Wt. :||158.11|
|Solubility:||H2O: 6 mg/mL (Need ultrasonic and warming)|
Ibotenic acid has agonist activity at both the N-methyl-D-aspartate (NMDA) and trans-ACPD or metabolotropic quisqualate (Qm) receptor sites. IC50 & Target: NMDA receptor In Vitro: Ibotenic acid (Ibo) is capable of acting at both NMDA and trans-ACPD receptors in the CNS, although only activation of NMDA receptors is involved in Ibo neurotoxicity. Ibotenic acid is toxic to cortical neurons exposes for 5 min with an EC50=77.3±8 μM (n=5) as measured by release of lactate dehydrogenase to the culture media.
Zinkand WC, et al. Ibotenic acid mediates neurotoxicity and phosphoinositide hydrolysis by independent receptormechanisms. Mol Chem Neuropathol. 1992 Feb-Apr;16(1-2):1-10.
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- CS-0020472 31798
- CS-0020472 30173
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