MK-0429
CAS No. : 227963-15-7

MK-0429
Cat. No. : CS-0003761
M. Wt. : 439.51
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  • Data Sheet

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Name: MK-0429; L-000845704
Cat. No. : CS-0003761
CAS No. : 227963-15-7
Formula: C23H29N5O4
M. Wt. : 439.51
Solubility: DMSO

Activity:

MK-0429 is a potent integrin antagonist with IC50s of 12.2 nM (α5β1 integrin) and 2.8 nM (αvβ3 integrin), respectively. IC50 & Target: IC50: 12.2 nM (α5β1 integrin), 2.8 nM (αvβ3 integrin), 1.6 nM (αvβ1 integrin), 0.7 nM (αvβ6 integrin), 0.5 nM (αvβ8 integrin), 0.1 nM (αvβ5 integrin)[1].

Protocol:

References:

Zhou X, et al. An integrin antagonist (MK-0429) decreases proteinuria and renal fibrosis in the ZSF1 rat diabetic nephropathy model.Pharmacol Res Perspect. 2017 Oct; 5 (5).

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