Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA
CAS No. : 199807-33-5

Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA
Cat. No. : CS-0062738
M. Wt. : 688.65
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1mg In-stock $120.0
5mg In-stock $380.0
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Name: Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA; 
Cat. No. : CS-0062738
CAS No. : 199807-33-5
Formula: C28H39F3N8O9
M. Wt. : 688.65
Solubility: 10 mM in DMSO

Activity:

Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) is an inhibitor of integrin αvβ3, with antitumor activity. IC50 & Target: αvβ3[1] In Vitro: Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) is an inhibitor of integrin αvβ3. Cyclo(Arg-Gly-Asp-D-Phe-Val) [c(RGDfV); 35 nM] induces disruption of leukemia cell migration and adhesion to leukemia osteoblasts in the 3D and 2D culture systems, affects the leukemia cell cycle and induces apoptosis in leukemia cells[1].

Protocol:

Cell Assay: [1]The osteoblasts are cultured in RPMI 1640 medium for 2 days. MV4-11 cells (1.8×105 cells/mL in the 2D culture system and 1×106 cells/mL in the 3D culture system) are co-cultured with leukemia osteoblasts in RPMI 1640 medium. The experiments used two groups: The experimental group received c(RGDfV) (35 nmol/mL) and the control group received an equal volume of phosphate-buffered saline (PBS) only[1].

References:

Shen ZH, et al. Targeting of the leukemia microenvironment by c(RGDfV) overcomes the resistance to chemotherapy in acute myeloid leukemia in biomimetic polystyrene scaffolds. Oncol Lett. 2016 Nov;12(5):3278-3284.

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