J-104132
CAS No. : 198279-45-7

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  • Data Sheet

  • Introduction

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Name: J-104132; L 753037
Cat. No. : CS-5666
CAS No. : 198279-45-7
Formula: C31H33NO7
M. Wt. : 531.60
Solubility: DMSO

Activity:

J-104132 is a potent, orally active ETA/ETB receptor antagonist, with Kis of 0.034 nM and 0.104 nM for cloned human ETA and ETB receptors expressed in CHO cells. IC50 & Target: Ki: 0.034 nM (human ETA receptor, CHO cell), 0.104 nM (human ETB receptor, CHO cell)[1] In Vitro: J-104132 is a potent, orally active mixed ETA/ETB receptor antagonist, with Kis of 0.034 nM and 0.104 nM for cloned human ETA and ETB receptors expressed in CHO cells. J-104132 also shows Ki of 0.350 ± 0.158 nM for ETA receptor in human uterus and 0.343 ± 0.146 nM for ETB receptor in human hippocampus[1].

Protocol:

References:

Nishikibe M, et al. Pharmacological properties of J-104132 (L-753,037), a potent, orally active, mixed ETA/ETB endothelin receptor antagonist. J Pharmacol Exp Ther. 1999 Jun;289(3):1262-70.

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