Linezolid

Linezolid
Cat. No. : CS-0756 CAS No. : 165800-03-3
M. Wt. : 337.3461
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Name: Linezolid; 
Cat. No. : CS-0756
CAS No. : 165800-03-3
Formula: C16H20FN3O4
M. Wt. : 337.3461
Solubility: 10 mM in DMSO

Activity:

Linezolid is a synthetic antibiotic used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics. IC50 value: Target: Antibiotic A member of the oxazolidinone class of drugs, linezolid is active against most Gram-positive bacteria that cause disease, including streptococci, vancomycin-resistant enterococci (VRE), and methicillin-resistant Staphylococcus aureus (MRSA).

Protocol:

References:

Karau MJ, Tilahun AY, Schmidt SM, Clark CR, Patel R, Rajagopalan G. Linezolid is Superior to Vancomycin in Experimental Pneumonia Caused by Superantigen-Producing Staphylococcus aureus in HLA class II Transgenic Mice. Antimicrob Agents Chemother. 2012 Jul 30.

Clemett D, Markham A. Linezolid. Drugs. 2000 Apr;59(4):815-27; discussion 828.

He MZ, Jiang YW, Cai C. Mechanisms and epidemiology of linezolid resistance in staphylococci.Zhonghua Jie He He Hu Xi Za Zhi. 2012 May;35(5):360-2.

Chiappini E, Conti C, Galli L et al. Clinical efficacy and tolerability of linezolid in pediatric patients: a systematic review. Clin Ther. 2010 Jan;32(1):66-88.

Perry CM, Jarvis B. Linezolid: a review of its use in the management of serious gram-positive infections. Drugs. 2001;61(4):525-51.

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