Integrin Antagonist 1 hydrochloride

Integrin Antagonist 1 hydrochloride
Cat. No. : CS-5443 CAS No. : 1629249-40-6
M. Wt. : 524.0973
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Name: Integrin Antagonist 1 hydrochloride; 
Cat. No. : CS-5443
CAS No. : 1629249-40-6
Formula: C29H38ClN5O2
M. Wt. : 524.0973
Solubility: DMSO: 11.66 mg/mL

Activity:

Integrin Antagonist 1 hydrochloride is a small molecule integrin αvβ6 antagonist, extracted from patent WO/2014154725A1, example 1. The affinity (pIC50) for the human - a 6 protein in the Fluorescence Polarisation Assay for Integrin Antagonist 1 was 8.1, whereas its affinity in the cell Adhesion Assays was for: ανβ6 (pIC50 = 8.4); ανβ3 (pIC50 = 6); ανβ5 (pIC50 = 6.9); ανβ8 (pIC50 = 7.7). IC50 value: 8.4 (pIC50) Target: αvβ6

Protocol:

References:

Anderson Niall Andrew, et al. Preparation of naphthyridine derivatives useful as αvβ6 integrin antagonists. From PCT Int. Appl. (2014), WO 2014154725 A1 20141002.

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