PCO371
CAS No. : 1613373-33-3

PCO371
Cat. No. : CS-0020524
M. Wt. : 635.65
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  • Data Sheet

  • Introduction

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  • COA & Spectra

Name: PCO371; 
Cat. No. : CS-0020524
CAS No. : 1613373-33-3
Formula: C29H32F3N5O6S
M. Wt. : 635.65
Solubility: DMSO

Activity:

PCO371 is an orally active full agonist of parathyroid hormone receptor 1 (PTHR1), with no effect on PTH type 2 receptor. IC50 & Target: PTHR1[1] In Vitro: PCO371 is an orally active full agonist of parathyroid hormone receptor 1 (PTHR1), with no effect on PTH type 2 receptor. PCO371 induces cAMP production with an EC50 of 2.4 μM in COS-7 cells expressing hPTHR1, and 2.5 μM in COS-7 cells transfected with hPTHR1-delNT, and also enhances the phospholipase C activity (EC50, 17 μM)[1].

Protocol:

References:

Tamura T, et al. Identification of an orally active small-molecule PTHR1 agonist for the treatment of hypoparathyroidism. Nat Commun. 2016 Nov 18;7:13384.

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