CAS No. : 152128-77-3
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|Name:||Emtricitabine S-oxide; Emtricitabine sulfoxide; Emtricitabine Degradant-III|
|Cat. No. :||CS-0018073|
|CAS No. :||152128-77-3|
|M. Wt. :||263.25|
Emtricitabine Degradant-III is a major degradation product of Emtricitabine. Emtricitabine is a potent nucleoside reverse transcriptase inhibitor used for the treatment of HIV infection.
IC50 & Target: Nucleoside reverse transcriptase
HIV In Vitro: Emtricitabine, an antiretroviral agent is used to evaluate degradation pathways under different stress conditions in order to identify degradation products as prescribed by ICH guidelines. Emtricitabine degrades over 51%, 13% and 53% during acid, base and oxidative degradation respectively followed by formation of three major degradation products (Degradant-I to Degradant-III).
A Prakash, et al. Forced degradation study of emtricitabine for evaluation of genotoxic impurity in active pharmaceutical ingredient's (API) shelf life. World Journal of Pharmacy and Pharmaceutical Sciences (2015), 4(7), 1909-1919.
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