Emtricitabine S-oxide
CAS No. : 152128-77-3

Emtricitabine S-oxide
Cat. No. : CS-0018073
M. Wt. : 263.25
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Name: Emtricitabine S-oxide; Emtricitabine sulfoxide; Emtricitabine Degradant-III
Cat. No. : CS-0018073
CAS No. : 152128-77-3
Formula: C8H10FN3O4S
M. Wt. : 263.25
Solubility: DMSO

Activity:

Emtricitabine Degradant-III is a major degradation product of Emtricitabine. Emtricitabine is a potent nucleoside reverse transcriptase inhibitor used for the treatment of HIV infection. IC50 & Target: Nucleoside reverse transcriptase[1]
HIV[1] In Vitro: Emtricitabine, an antiretroviral agent is used to evaluate degradation pathways under different stress conditions in order to identify degradation products as prescribed by ICH guidelines. Emtricitabine degrades over 51%, 13% and 53% during acid, base and oxidative degradation respectively followed by formation of three major degradation products (Degradant-I to Degradant-III)[1].

Protocol:

References:

A Prakash, et al. Forced degradation study of emtricitabine for evaluation of genotoxic impurity in active pharmaceutical ingredient's (API) shelf life. World Journal of Pharmacy and Pharmaceutical Sciences (2015), 4(7), 1909-1919.

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