Glycyrrhizic acid

Glycyrrhizic acid
Cat. No. : CS-7695 CAS No. : 1405-86-3
M. Wt. : 822.93208
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25g In-stock $83.0
100g 1-5days $248.0
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Name: Glycyrrhizic acid; Glycyrrhizin
Cat. No. : CS-7695
CAS No. : 1405-86-3
Formula: C42H62O16
M. Wt. : 822.93208
Solubility: DMSO: ≥ 10 mM

Activity:

Glycyrrhizic acid is a triterpenoid saponinl, extracted from the licorice root, with anti-tumor, anti-diabetic activities. In Vitro: Glycyrrhizic acid shows a series of anti-cancer-related pharmacological activities, such as broad-spectrum anti-cancer ability, resistance to the tissue toxicity caused by chemotherapy and radiation, drug absorption enhancing effects and anti-multidrug resistance (MDR) mechanisms, as a carrier material in drug delivery systems[1]. In intestinal NCI-H716 cells that secretes GLP-1, Glycyrrhizic acid promotes GLP-1 secretion with a marked elevation of calcium levels. Glycyrrhizic acid can enhance GLP-1 secretion through TGR5 activation[2]. In Vivo: In type 1-like diabetic rats induced by streptozotocin (STZ-treated rats), Glycyrrhizic acid increases the level of plasma GLP-1, which is blocked by triamterene at a dose sufficient to inhibit Takeda G-protein-coupled receptor 5 (TGR5)[1].

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References:

Su X, et al. Glycyrrhizic acid: A promising carrier material for anticancer therapy. Biomed Pharmacother. 2017 Sep 5;95:670-678

Wang LY, et al. Glycyrrhizic acid increases glucagon like peptide-1 secretion via TGR5 activation in type 1-like diabetic rats. Biomed Pharmacother. 2017 Sep 4;95:599-604.

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