SNT-207707
CAS No. : 1064662-40-3

SNT-207707
Cat. No. : CS-0003000
M. Wt. : 550.18
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  • Data Sheet

  • Introduction

  • SDS

  • COA & Spectra

Name: SNT-207707; Imidazo[1,2-a]pyridine-6-carboxamide, 2-(4-cyanophenyl)-N,N-bis(3-methylbutyl)-3-[3-(1-pyrrolidinyl)propyl]-, hydrochloride (1:1)
Cat. No. : CS-0003000
CAS No. : 1064662-40-3
Formula: C32H44ClN5O
M. Wt. : 550.18
Solubility: DMSO

Activity:

SNT-207707 is a selective, potent and orally active melanocortin MC-4 receptor antagonist with an IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor. IC50 & Target: IC50: 8 nM (binding MC-4), 5 nM (function MC-4)[1] In Vitro: SNT-207707 binds to the MC-4 receptor with an affinity of 8 nM and shows a more than 200-fold selectivity vs. MC-3 and MC-5. SNT207858 is a 22 nM MC-4 antagonist with a 170-fold selectivity vs. MC-3 and a 40-fold selectivity versus MC-5[1]. In Vivo: Single subcutaneous injection of 20 mg/kg of SNT-207707 distinctly increases food intake of the mice. Once daily oral administration of both compounds SNT207858 and SNT-207707 starting the day after tumor implantation significantly reduces the tumor induced weight loss[1].

Protocol:

Animal Administration: SNT-207707 is freshly dissolved and administered by oral gavage in a volume of 10 mL/kg of 10% Hydroxypropyl-β-cyclodextrin in 100 mM saline solution[1].[1]Mice[1]

Twelve weeks old male CD-1 mice are dosed by gavage with either SNT-207707 or SNT207858 at 60 mg/kg (n=9 per compound). At 1, 3, and 6 hrs post-dose, 3 mice from each compound group are euthanized with CO2. Blood is collected by cardiac puncture, plasma is isolated immediately and then kept on dry ice until analysis[1].

References:

Weyermann P, et al. Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice. PLoS One. 2009;4(3):e4774.

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